{"id":6063,"date":"2021-10-26T07:00:00","date_gmt":"2021-10-26T07:00:00","guid":{"rendered":"https:\/\/youngentrepreneursinscience.com\/?p=6063"},"modified":"2022-09-16T10:23:10","modified_gmt":"2022-09-16T10:23:10","slug":"drop-by-drop-to-better-diagnoses","status":"publish","type":"post","link":"https:\/\/youngentrepreneursinscience.com\/de\/2021\/10\/26\/drop-by-drop-to-better-diagnoses\/","title":{"rendered":"Drop by drop to better diagnoses"},"content":{"rendered":"<div id=\"YES-BlogText-1\" class=\"YES-BlogText col-12\">\n\n  <div class=\"row\">\n        <div class=\"col-12 col-lg-2\">\n      <span class=\"posted-on\">Ver\u00f6ffentlicht am <br><strong><time class=\"entry-date published updated\" datetime=\"2021-10-26T07:00:00+01:00\">26 Oktober, 2021<\/time><\/strong><\/span><br><br><span class=\"posted-by\"> Written by<br><strong><span class=\"author vcard\">Svenja Prigge<\/span><\/strong><\/span>    <\/div>\n    \n    <div\n      class=\"col-12 col-lg-8 \">\n      <h2>How a new biosensor could prevent malaria deaths<\/h2>\n<p class=\"lead\">When it comes to battling infectious diseases, early detection is essential. Before prescribing adequate treatment, doctors should be able to quickly identify what kind of parasites the patient is fighting against. Easier said than done. Sometimes, a person\u2019s life depends on only a couple of hours \u2013 but what if prevalent testing methods aren\u2019t precise or fast enough? <a href=\"https:\/\/www.linkedin.com\/in\/gabriela-figueroa-miranda\/\">Gabriela Figueroa Miranda<\/a> has been working on a user-friendly biosensor that will enable patients and doctors alike to identify specific malaria parasites in the blood.<\/p>\n    <\/div>\n\n      <\/div>\n\n<\/div>\n\n<div id=\"YES-BlogText-2\" class=\"YES-BlogText col-12\">\n\n  <div class=\"row\">\n    \n    <div\n      class=\"col-12 col-lg-8  offset-lg-2 \">\n      <h5>What are aptamers and what do they have to do with battling malaria disease?<\/h5>\n<p>Aptamers are short single-strand DNA or RNA molecule sequences. Their most important characteristic is that they bind with high affinity to a specific target, like the biomolecules of malaria parasites. This is how our biosensor recognises malaria in the blood of patients. Aptamers are synthesised artificially. No experiment animals needed!<\/p>\n<h5>What is the standard of malaria detection thus far?<\/h5>\n<p>The standard is microscopy, which is time-consuming. Only a trained person can identify a parasite in the blood sample. There are rapid diagnostic tests that work like COVID tests, but they are less stable in higher temperatures and can only tell you whether you are infected or not.<\/p>\n    <\/div>\n\n      <\/div>\n\n<\/div>\n\n<div id=\"YES-BlogCite-3\" class=\"YES-BlogCite col-12\">\n  <div class=\"row\">\n    <div class=\"col-12 col-lg-8 offset-lg-2 text-center\">\n            <div class=\"quote\">\u201cOur device is more sensitive than any rapid test.\u201d<\/div>\n                <\/div>\n  <\/div>\n<\/div>\n\n<div id=\"YES-BlogText-4\" class=\"YES-BlogText col-12\">\n\n  <div class=\"row\">\n    \n    <div\n      class=\"col-12 col-lg-8  offset-lg-2 \">\n      <h5>How would your biosensor work?<\/h5>\n<p>In principle, it would work like a glucometre. The patient puts a drop of their blood on the sensor and can read their results from the screen of a small device. The sensor will provide extra information, such as the number of parasites present in the blood. Our device is more sensitive than any rapid test. We can detect as low as 50 parasites per microlitre. Thus, the result is not only qualitative but also quantitative.<\/p>\n<h5>\u2026 which is essential for choosing the proper treatment.<\/h5>\n<p>Exactly, our biosensor can detect various biomarkers in the same sample. That allows us to discriminate between different malaria parasites. This way, a doctor or paramedic will know which medication is required, and how much.<\/p>\n<h5>What needs to happen before rolling out the prototypes for the sensors?<\/h5>\n<p>In the beginning, I thought that we had everything ready to launch our sensor onto the market. I soon realised that we had developed a sensor at the lab scale, not a product for anybody to use on their own. We are currently working on optimising the design. Any person, not only doctors, should be able to use our sensor.<\/p>\n    <\/div>\n\n      <\/div>\n\n<\/div>\n\n<div id=\"YES-BlogCite-5\" class=\"YES-BlogCite col-12\">\n  <div class=\"row\">\n    <div class=\"col-12 col-lg-8 offset-lg-2 text-center\">\n            <div class=\"headline\">Gabriela\u2019s Tip<\/div>\n            <div class=\"quote\">\u201cGet to know your customers as early as possible, and let them test your prototype. Only then you will realise if your product is really needed and useful out there.\u201d <\/div>\n            <div class=\"author\">Gabriela Figueroa Miranda<\/div>\n                  <div class=\"author-position\">Young Entrepreneurs in Science Alumna<\/div>\n          <\/div>\n  <\/div>\n<\/div>\n\n<div id=\"YES-BlogText-6\" class=\"YES-BlogText col-12\">\n\n  <div class=\"row\">\n    \n    <div\n      class=\"col-12 col-lg-8  offset-lg-2 \">\n      <h5>Was it always part of your research to develop something applicable?<\/h5>\n<p>It was not my aim to end up with a product, but \u2013 due to the promising results of my research \u2013 I realised its potential. The question of \u201cWhy not\u201d kept growing bigger. With the help and support of my supervisor at Forschungszentrum J\u00fclich, I successfully pitched my idea to my technology transfer department. They are supporting me financially. Together with my colleague Viviana Rinc\u00f3n Montes I have been working on the optimisation of the biosensor to make it more user-friendly. We are currently also writing applications for funding to support the further development.<\/p>\n<h5>What would you do with your first funding?<\/h5>\n<p>We want to go to the clinical trial, which are part of the certification for in vitro diagnostics. We need the certificate to prove that our product is effective. A part of the money would go to the investment in machines. It is important to standardise and optimise everything before going to mass production. It is not the same to fabricate one sensor in the lab as opposed to 100,000 in a production facility.<\/p>\n    <\/div>\n\n      <\/div>\n\n<\/div>\n\n<div id=\"YES-BlogCite-7\" class=\"YES-BlogCite col-12\">\n  <div class=\"row\">\n    <div class=\"col-12 col-lg-8 offset-lg-2 text-center\">\n            <div class=\"quote\">\u201cIn science, soft skills are not the main focus, yet they are essential for entrepreneurship.\u201d<\/div>\n                <\/div>\n  <\/div>\n<\/div>\n\n<div id=\"YES-BlogText-8\" class=\"YES-BlogText col-12\">\n\n  <div class=\"row\">\n    \n    <div\n      class=\"col-12 col-lg-8  offset-lg-2 \">\n      <h5>What is the day-to-day of your job?<\/h5>\n<p>I frequently check in with my research team, write applications, and attend workshops, such as the Young Entrepreneurs in Science Workshop. Each day, we learn more about building a startup. We are now participating in an ideation programme at RWTH Aachen that provides us with a coach to help us with our business model. In science, soft skills are not the main focus, yet they are essential for entrepreneurship. This is why I loved the YES programme. In the prototyping session, we learned how to build something fast to show to investors without having a finished product. The teamwork in the breakout sessions was a great chance to receive feedback.<\/p>\n<h5>How do you deal with the uncertainty of entrepreneurship?<\/h5>\n<p>I take things one step at a time, but of course, there are always many open questions waiting to be addressed!<\/p>\n    <\/div>\n\n      <\/div>\n\n<\/div>","protected":false},"excerpt":{"rendered":"<p>When it comes to battling infectious diseases, early detection is essential. Gabriela Figueroa Miranda has been working on a user-friendly biosensor that will enable patients and doctors alike to identify specific malaria parasites in the blood.<\/p>\n","protected":false},"author":3,"featured_media":6080,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[189],"tags":[],"class_list":["post-6063","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Drop by drop to better diagnoses - YES<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/youngentrepreneursinscience.com\/de\/2021\/10\/26\/drop-by-drop-to-better-diagnoses\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Drop by drop to better diagnoses - YES\" \/>\n<meta property=\"og:description\" content=\"When it comes to battling infectious diseases, early detection is essential. 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