{"id":4558,"date":"2020-05-26T07:00:00","date_gmt":"2020-05-26T07:00:00","guid":{"rendered":"https:\/\/youngentrepreneursinscience.com\/?p=4558"},"modified":"2022-09-16T12:16:43","modified_gmt":"2022-09-16T12:16:43","slug":"getting-ahead-of-alzheimers-disease","status":"publish","type":"post","link":"https:\/\/youngentrepreneursinscience.com\/de\/2020\/05\/26\/getting-ahead-of-alzheimers-disease\/","title":{"rendered":"Getting ahead of Alzheimer\u2019s disease"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\"><\/h2>\n\n\n<div id=\"YES-BlogText-1\" class=\"YES-BlogText col-12\">\n\n  <div class=\"row\">\n        <div class=\"col-12 col-lg-2\">\n      <span class=\"posted-on\">Ver\u00f6ffentlicht am <br><strong><time class=\"entry-date published updated\" datetime=\"2020-05-26T07:00:00+01:00\">26 Mai, 2020<\/time><\/strong><\/span><br><br><span class=\"posted-by\"> Written by<br><strong><span class=\"author vcard\">Svenja Prigge<\/span><\/strong><\/span>    <\/div>\n    \n    <div\n      class=\"col-12 col-lg-8 \">\n      <h2>This researcher\u2019s startup idea could enable earlier diagnoses and path the way for a cure.<\/h2>\n<p class=\"lead\">Forget about conventional memory tests! Cognitive neuroscience researcher <a href=\"https:\/\/www.linkedin.com\/in\/nadine-diersch\">Nadine Diersch<\/a> from the DZNE in Magdeburg is exploring new ways to diagnose Alzheimer\u2019s disease with the help of a universal device: our smartphone. Her app prototype is a chance for people at risk to get ahead of time, opening up possibilities for treating the incurable disease.<\/p>\n    <\/div>\n\n      <\/div>\n\n<\/div>\n\n<div id=\"YES-BlogText-2\" class=\"YES-BlogText col-12\">\n\n  <div class=\"row\">\n    \n    <div\n      class=\"col-12 col-lg-8  offset-lg-2 \">\n      <h4>When did you start taking interest in Alzheimer\u2019s disease?<\/h4>\n<p>During my studies I did an internship in a neurorehabilitation clinic in Switzerland, where I had direct contact with Alzheimer\u2019s patients as well as patients who suffered from a stroke. I was amazed by the plasticity of the brain and the positive effects of training over time. Since I started working at the <b><a href=\"https:\/\/www.dzne.de\/\">DZNE<\/a><\/b> in Magdeburg, which is the German Centre for Neurodegenerative Diseases, I have grown even more interested in neurodegeneration and Alzheimer\u2019s disease in particular.<\/p>\n<h4>For which there is no cure as of now \u2026<\/h4>\n<p>True, but there is a lot of progress in research on cognitive neuroscience of ageing at the moment. We have learned that protein accumulations in certain brain regions might be one of the first signs of a pathologically ageing brain \u2013 many years before a person exhibits any signs of the typical memory loss. Interestingly, the proteins begin to accumulate in brain regions that are known to contain our \u201cinternal GPS system\u201d. Our research group at DZNE focuses on this age-related decline in spatial navigation, which could be an important indicator to detect and target Alzheimer\u2019s disease at a much earlier stage.<\/p>\n    <\/div>\n\n      <\/div>\n\n<\/div>\n\n<div id=\"YES-BlogImage-3\" class=\"YES-BlogImage col-12 my-5 pb-5\">\n  <figure class=\"figure\">\n    <img loading=\"lazy\" decoding=\"async\" width=\"2000\" height=\"1168\" src=\"https:\/\/youngentrepreneursinscience.com\/wp-content\/uploads\/2022\/06\/Infografik_Gitterzellen_weiss_SCREENmitBildQuelle.jpg\" class=\"img-fluid\" alt=\"Our internal GPS system: the place and grid cells of the hippocampus and entorhinal cortex, by which we determine our position in a space. This is where protein accumulations occur in early stages. Source: DZNE\/Daniela Leitner\" srcset=\"https:\/\/youngentrepreneursinscience.com\/wp-content\/uploads\/2022\/06\/Infografik_Gitterzellen_weiss_SCREENmitBildQuelle.jpg 2000w, https:\/\/youngentrepreneursinscience.com\/wp-content\/uploads\/2022\/06\/Infografik_Gitterzellen_weiss_SCREENmitBildQuelle-300x175.jpg 300w, https:\/\/youngentrepreneursinscience.com\/wp-content\/uploads\/2022\/06\/Infografik_Gitterzellen_weiss_SCREENmitBildQuelle-1024x598.jpg 1024w, https:\/\/youngentrepreneursinscience.com\/wp-content\/uploads\/2022\/06\/Infografik_Gitterzellen_weiss_SCREENmitBildQuelle-768x449.jpg 768w, https:\/\/youngentrepreneursinscience.com\/wp-content\/uploads\/2022\/06\/Infografik_Gitterzellen_weiss_SCREENmitBildQuelle-1536x897.jpg 1536w, https:\/\/youngentrepreneursinscience.com\/wp-content\/uploads\/2022\/06\/Infografik_Gitterzellen_weiss_SCREENmitBildQuelle-171x100.jpg 171w\" sizes=\"auto, (max-width: 2000px) 100vw, 2000px\" \/><figcaption class=\"figure-caption text-end mt-2\">Our internal GPS system: the place and grid cells of the hippocampus and entorhinal cortex, by which we determine our position in a space. This is where protein accumulations occur in early stages. \r\nSource: DZNE\/Daniela Leitner<\/figcaption>  <\/figure>\n<\/div>\n\n<div id=\"YES-BlogText-4\" class=\"YES-BlogText col-12\">\n\n  <div class=\"row\">\n    \n    <div\n      class=\"col-12 col-lg-8  offset-lg-2 \">\n      <h5>What sparked the idea to turn your research into a product?<\/h5>\n<p>We typically place our participants in a Virtual Reality model and ask them to point towards certain locations in the virtual environment, for instance. However, this form of navigation can obviously be very confined. I\u2019m an outdoorsy person and like to go on hikes using tracking apps. At some point I wondered: What about our walking patterns, the paths we take? Why not use data from our smartphones to study our questions? We all carry our smartphones with us all the time! Using our mobile devices, we have an opportunity to see whether movement patterns during navigation in the real world can be used to detect early changes in the brain \u2013 in an easy-to-apply and cost-effective manner!<\/p>\n    <\/div>\n\n      <\/div>\n\n<\/div>\n\n<div id=\"YES-BlogImage-5\" class=\"YES-BlogImage col-12 my-5 pb-5\">\n  <figure class=\"figure\">\n    <img loading=\"lazy\" decoding=\"async\" width=\"2560\" height=\"1707\" src=\"https:\/\/youngentrepreneursinscience.com\/wp-content\/uploads\/2022\/06\/190509_TTFW_PHT44-scaled.jpg\" class=\"img-fluid\" alt=\"Nadine in discussion with her team during the Young Entrepreneurs in Science workshop in Berlin\" srcset=\"https:\/\/youngentrepreneursinscience.com\/wp-content\/uploads\/2022\/06\/190509_TTFW_PHT44-scaled.jpg 2560w, https:\/\/youngentrepreneursinscience.com\/wp-content\/uploads\/2022\/06\/190509_TTFW_PHT44-300x200.jpg 300w, https:\/\/youngentrepreneursinscience.com\/wp-content\/uploads\/2022\/06\/190509_TTFW_PHT44-1024x683.jpg 1024w, https:\/\/youngentrepreneursinscience.com\/wp-content\/uploads\/2022\/06\/190509_TTFW_PHT44-768x512.jpg 768w, https:\/\/youngentrepreneursinscience.com\/wp-content\/uploads\/2022\/06\/190509_TTFW_PHT44-1536x1024.jpg 1536w, https:\/\/youngentrepreneursinscience.com\/wp-content\/uploads\/2022\/06\/190509_TTFW_PHT44-2048x1365.jpg 2048w, https:\/\/youngentrepreneursinscience.com\/wp-content\/uploads\/2022\/06\/190509_TTFW_PHT44-150x100.jpg 150w\" sizes=\"auto, (max-width: 2560px) 100vw, 2560px\" \/><figcaption class=\"figure-caption text-end mt-2\">Nadine (3rd from left) in discussion with her team during the Young Entrepreneurs in Science workshop in Berlin\r\n\u00a9 Falling Walls, Thomas Trutschel\/photothek <\/figcaption>  <\/figure>\n<\/div>\n\n<div id=\"YES-BlogText-6\" class=\"YES-BlogText col-12\">\n\n  <div class=\"row\">\n    \n    <div\n      class=\"col-12 col-lg-8  offset-lg-2 \">\n      <h5>You pitched the idea during the Young Entrepreneurs in Science workshop in Berlin \u2026<\/h5>\n<p>It was very helpful to talk to people outside of my domain and to look at what defining a product looks like beyond the pure research questions. I am trained as a researcher, but now I need to sell a product! All of a sudden, I am facing questions that I never had to face in my research project. It was very valuable to have an audience and get feedback. I had the feeling that my idea generated interest, which encouraged me to move along with it. In addition, developing a business model canvas for the project helped me to refine my idea.<\/p>\n<h5>Which will be the next steps to take?<\/h5>\n<p>I acquired some internal funding from the Innovation to Application Award, issued by the DZNE. This allows me to realize the first application prototype together with a software development company and conduct the first proof of concept studies in Magdeburg on our campus. The next step is to acquire more funding over the course of this or next year, depending on how much the Covid-19 pandemic will impact our research timeline.<\/p>\n    <\/div>\n\n      <\/div>\n\n<\/div>\n\n<div id=\"YES-BlogCite-7\" class=\"YES-BlogCite col-12\">\n  <div class=\"row\">\n    <div class=\"col-12 col-lg-8 offset-lg-2 text-center\">\n            <div class=\"headline\">Nadine\u2019s Tip<\/div>\n            <div class=\"quote\">\u201cFor somebody who wants to become an entrepreneur, it is crucial to be proactive in order to build up a network outside your lab.\u201d<\/div>\n            <div class=\"author\">Nadine Diersch<\/div>\n                  <div class=\"author-position\">Young Entrepreneurs in Science Alumna<\/div>\n          <\/div>\n  <\/div>\n<\/div>\n\n<div id=\"YES-BlogText-8\" class=\"YES-BlogText col-12\">\n\n  <div class=\"row\">\n    \n    <div\n      class=\"col-12 col-lg-8  offset-lg-2 \">\n      <h5>What are you looking forward to as a soon-to-be entrepreneur?<\/h5>\n<p>As a researcher, I like data! The DZNE is the perfect environment to collect data from different age and patient groups to further validate the idea and develop a machine learning algorithm that is able to detect abnormalities in the movement patterns. Translating the research results into a product, together with a team of other experts such as software developers and business experts, is a perspective that I find exciting!<\/p>\n    <\/div>\n\n      <\/div>\n\n<\/div>\n\n<div id=\"YES-BlogCite-9\" class=\"YES-BlogCite col-12\">\n  <div class=\"row\">\n    <div class=\"col-12 col-lg-8 offset-lg-2 text-center\">\n            <div class=\"quote\">\u201cAs scientists, we tap into a variety of different skills.\u201c<\/div>\n                <\/div>\n  <\/div>\n<\/div>\n\n<div id=\"YES-BlogText-10\" class=\"YES-BlogText col-12\">\n\n  <div class=\"row\">\n    \n    <div\n      class=\"col-12 col-lg-8  offset-lg-2 \">\n      <h5>How to benefit from being a researcher with regard to starting a business?<\/h5>\n<p>As scientists, we tap into a variety of different skills to implement, analyze, communicate and also finance our research. During my PhD, I learned to work independently and adapt to changes. I am optimistic that these skills will also help me in the private sector \u2022<\/p>\n    <\/div>\n\n      <\/div>\n\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Cognitive neuroscience researcher Nadine Diersch from the DZNE in Magdeburg is exploring new ways to diagnose Alzheimer\u2019s disease \u2026<\/p>\n","protected":false},"author":3,"featured_media":5195,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[189],"tags":[],"class_list":["post-4558","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Getting ahead of Alzheimer\u2019s disease - YES<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/youngentrepreneursinscience.com\/de\/2020\/05\/26\/getting-ahead-of-alzheimers-disease\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Getting ahead of Alzheimer\u2019s disease - YES\" \/>\n<meta property=\"og:description\" content=\"Cognitive neuroscience researcher Nadine Diersch from the DZNE in Magdeburg is exploring new ways to diagnose Alzheimer\u2019s disease \u2026\" \/>\n<meta property=\"og:url\" content=\"https:\/\/youngentrepreneursinscience.com\/de\/2020\/05\/26\/getting-ahead-of-alzheimers-disease\/\" \/>\n<meta property=\"og:site_name\" content=\"YES\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/YoungEntrepreneursinScience\/\" \/>\n<meta property=\"article:published_time\" content=\"2020-05-26T07:00:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-09-16T12:16:43+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/youngentrepreneursinscience.com\/wp-content\/uploads\/2020\/05\/YoungEntrepreneurs_Newsletter-3_Kati-Szilagyi.jpeg\" \/>\n\t<meta property=\"og:image:width\" content=\"1920\" \/>\n\t<meta property=\"og:image:height\" content=\"1920\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Svenja Prigge\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@yeis_fw\" \/>\n<meta name=\"twitter:site\" content=\"@yeis_fw\" \/>\n<meta name=\"twitter:label1\" content=\"Geschrieben von\" \/>\n\t<meta name=\"twitter:data1\" content=\"Svenja Prigge\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/youngentrepreneursinscience.com\/de\/2020\/05\/26\/getting-ahead-of-alzheimers-disease\/\",\"url\":\"https:\/\/youngentrepreneursinscience.com\/de\/2020\/05\/26\/getting-ahead-of-alzheimers-disease\/\",\"name\":\"Getting ahead of Alzheimer\u2019s disease - YES\",\"isPartOf\":{\"@id\":\"https:\/\/youngentrepreneursinscience.com\/de\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/youngentrepreneursinscience.com\/de\/2020\/05\/26\/getting-ahead-of-alzheimers-disease\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/youngentrepreneursinscience.com\/de\/2020\/05\/26\/getting-ahead-of-alzheimers-disease\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/youngentrepreneursinscience.com\/wp-content\/uploads\/2020\/05\/YoungEntrepreneurs_Newsletter-3_Kati-Szilagyi.jpeg\",\"datePublished\":\"2020-05-26T07:00:00+00:00\",\"dateModified\":\"2022-09-16T12:16:43+00:00\",\"author\":{\"@id\":\"https:\/\/youngentrepreneursinscience.com\/de\/#\/schema\/person\/fa9b1f9e5dc09cd403a3c36ead3958ab\"},\"breadcrumb\":{\"@id\":\"https:\/\/youngentrepreneursinscience.com\/de\/2020\/05\/26\/getting-ahead-of-alzheimers-disease\/#breadcrumb\"},\"inLanguage\":\"de\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/youngentrepreneursinscience.com\/de\/2020\/05\/26\/getting-ahead-of-alzheimers-disease\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"de\",\"@id\":\"https:\/\/youngentrepreneursinscience.com\/de\/2020\/05\/26\/getting-ahead-of-alzheimers-disease\/#primaryimage\",\"url\":\"https:\/\/youngentrepreneursinscience.com\/wp-content\/uploads\/2020\/05\/YoungEntrepreneurs_Newsletter-3_Kati-Szilagyi.jpeg\",\"contentUrl\":\"https:\/\/youngentrepreneursinscience.com\/wp-content\/uploads\/2020\/05\/YoungEntrepreneurs_Newsletter-3_Kati-Szilagyi.jpeg\",\"width\":1920,\"height\":1920,\"caption\":\"An illustration showing a head. 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